Breathing pattern in patients with Parkinson’s disease
Identifieur interne : 001934 ( Main/Corpus ); précédent : 001933; suivant : 001935Breathing pattern in patients with Parkinson’s disease
Auteurs : Laurent Vercueil ; Jean Pierre Linard ; Bernard Wuyam ; Pierre Pollak ; Gila BenchetritSource :
- Respiration Physiology [ 0034-5687 ] ; 1999.
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- KwdEn :
Abstract
The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.
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DOI: 10.1016/S0034-5687(99)00075-4
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ISTEX:3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7Le document en format XML
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Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</mods:affiliation></affiliation></author><author><name sortKey="Benchetrit, Gila" sort="Benchetrit, Gila" uniqKey="Benchetrit G" first="Gila" last="Benchetrit">Gila Benchetrit</name><affiliation><mods:affiliation>E-mail: gila.benchetrit@imag.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno 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gila.benchetrit@imag.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Respiration Physiology</title><title level="j" type="abbrev">RESP</title><idno type="ISSN">0034-5687</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">118</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="163">163</biblScope><biblScope unit="page" to="172">172</biblScope></imprint><idno type="ISSN">0034-5687</idno></series><idno type="istex">3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</idno><idno type="DOI">10.1016/S0034-5687(99)00075-4</idno><idno type="PII">S0034-5687(99)00075-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0034-5687</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease, Parkinson</term><term>Mammals, humans</term><term>Pattern of breathing, Parkinson’s disease</term><term>Pharmacological agents, levodopa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Laurent Vercueil</name><affiliations><json:string>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</json:string></affiliations></json:item><json:item><name>Jean Pierre Linard</name><affiliations><json:string>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</json:string></affiliations></json:item><json:item><name>Bernard Wuyam</name><affiliations><json:string>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</json:string></affiliations></json:item><json:item><name>Pierre Pollak</name><affiliations><json:string>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</json:string></affiliations></json:item><json:item><name>Gila Benchetrit</name><affiliations><json:string>E-mail: gila.benchetrit@imag.fr</json:string><json:string>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Disease, Parkinson</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mammals, humans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pattern of breathing, Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pharmacological agents, levodopa</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</abstract><qualityIndicators><score>6.823</score><pdfVersion>1.2</pdfVersion><pdfPageSize>536 x 674 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1420</abstractCharCount><pdfWordCount>4123</pdfWordCount><pdfCharCount>26343</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>225</abstractWordCount></qualityIndicators><title>Breathing pattern in patients with Parkinson’s disease</title><pii><json:string>S0034-5687(99)00075-4</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>II</volume><editor><json:item><name>S. Fahn</name></json:item><json:item><name>C.D. Marsden</name></json:item><json:item><name>D.B. Calne</name></json:item><json:item><name>M. Goldstein</name></json:item></editor><pages><last>163</last><first>153</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Recent Developments in Parkinsons Disease</title></serie><host><volume>118</volume><pii><json:string>S0034-5687(00)X0051-5</json:string></pii><pages><last>172</last><first>163</first></pages><issn><json:string>0034-5687</json:string></issn><issue>2–3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Respiration Physiology</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>RESPIRATORY SYSTEM</json:string><json:string>PHYSIOLOGY</json:string></wos></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0034-5687(99)00075-4</json:string></doi><id>3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Breathing pattern in patients with Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1999</date></publicationStmt><notesStmt><note type="content">Fig. 1: Ventilatory pattern and mean rib cage versus mean abdomen plot in Off and On condition in patients with Parkinson’s disease. Rib cage and abdomen signals were recorded by inductance plethysmographie and mean signals for each recording were calculated from Fourier coefficients calculated breath by breath.</note><note type="content">Table 1: Patient’s characteristics</note><note type="content">Table 2: Clinical data in Off and On (in italics) conditionsa</note><note type="content">Table 3: Ventilatory data in Off and On (in italic) conditions</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Breathing pattern in patients with Parkinson’s disease</title><author><persName><forename type="first">Laurent</forename><surname>Vercueil</surname></persName><affiliation>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</affiliation></author><author><persName><forename type="first">Jean Pierre</forename><surname>Linard</surname></persName><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation></author><author><persName><forename type="first">Bernard</forename><surname>Wuyam</surname></persName><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation></author><author><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><affiliation>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</affiliation></author><author><persName><forename type="first">Gila</forename><surname>Benchetrit</surname></persName><email>gila.benchetrit@imag.fr</email><note type="correspondence"><p>Corresponding author. Tel.: +33-4-76-63-71-06; fax: +33-4-76-63-71-86</p></note><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation></author></analytic><monogr><title level="j">Respiration Physiology</title><title level="j" type="abbrev">RESP</title><idno type="pISSN">0034-5687</idno><idno type="PII">S0034-5687(00)X0051-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">118</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="163">163</biblScope><biblScope unit="page" to="172">172</biblScope></imprint></monogr><idno type="istex">3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</idno><idno type="DOI">10.1016/S0034-5687(99)00075-4</idno><idno type="PII">S0034-5687(99)00075-4</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Disease, Parkinson</term></item><item><term>Mammals, humans</term></item><item><term>Pattern of breathing, Parkinson’s disease</term></item><item><term>Pharmacological agents, levodopa</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-07-21">Registration</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>RESP</jid><aid>2814</aid><ce:pii>S0034-5687(99)00075-4</ce:pii><ce:doi>10.1016/S0034-5687(99)00075-4</ce:doi><ce:copyright type="full-transfer" year="1999">Elsevier Science B.V.</ce:copyright></item-info><head><ce:title>Breathing pattern in patients with Parkinson’s disease</ce:title><ce:author-group><ce:author><ce:given-name>Laurent</ce:given-name><ce:surname>Vercueil</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jean Pierre</ce:given-name><ce:surname>Linard</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Bernard</ce:given-name><ce:surname>Wuyam</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Pierre</ce:given-name><ce:surname>Pollak</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gila</ce:given-name><ce:surname>Benchetrit</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>gila.benchetrit@imag.fr</ce:e-address></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +33-4-76-63-71-06; fax: +33-4-76-63-71-86</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="21" month="7" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (O<ce:small-caps>ff</ce:small-caps>) and after (O<ce:small-caps>n</ce:small-caps>) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the O<ce:small-caps>ff</ce:small-caps> condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the O<ce:small-caps>n</ce:small-caps> condition. Breath-by-breath processing of recordings was carried out and tidal volume (V<ce:small-caps>t</ce:small-caps>), inspiratory (T<ce:small-caps>i</ce:small-caps>) and expiratory (T<ce:small-caps>e</ce:small-caps>) durations were measured. The main finding was a lengthening of T<ce:small-caps>i</ce:small-caps> resulting in a decrease in ventilation and in V<ce:small-caps>t</ce:small-caps>/T<ce:small-caps>i,</ce:small-caps> and an increase in T<ce:small-caps>i</ce:small-caps>/T<ce:small-caps>tot</ce:small-caps> in the O<ce:small-caps>n</ce:small-caps> compared to the O<ce:small-caps>ff</ce:small-caps> condition. In the O<ce:small-caps>n</ce:small-caps> condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Disease, Parkinson</ce:text></ce:keyword><ce:keyword><ce:text>Mammals, humans</ce:text></ce:keyword><ce:keyword><ce:text>Pattern of breathing, Parkinson’s disease</ce:text></ce:keyword><ce:keyword><ce:text>Pharmacological agents, levodopa</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Breathing pattern in patients with Parkinson’s disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Breathing pattern in patients with Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">Laurent</namePart><namePart type="family">Vercueil</namePart><affiliation>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean Pierre</namePart><namePart type="family">Linard</namePart><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Wuyam</namePart><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><affiliation>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gila</namePart><namePart type="family">Benchetrit</namePart><affiliation>E-mail: gila.benchetrit@imag.fr</affiliation><affiliation>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche, France</affiliation><description>Corresponding author. Tel.: +33-4-76-63-71-06; fax: +33-4-76-63-71-86</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateValid encoding="w3cdtf">1999-07-21</dateValid><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</abstract><note type="content">Fig. 1: Ventilatory pattern and mean rib cage versus mean abdomen plot in Off and On condition in patients with Parkinson’s disease. Rib cage and abdomen signals were recorded by inductance plethysmographie and mean signals for each recording were calculated from Fourier coefficients calculated breath by breath.</note><note type="content">Table 1: Patient’s characteristics</note><note type="content">Table 2: Clinical data in Off and On (in italics) conditionsa</note><note type="content">Table 3: Ventilatory data in Off and On (in italic) conditions</note><subject lang="en"><genre>Keywords</genre><topic>Disease, Parkinson</topic><topic>Mammals, humans</topic><topic>Pattern of breathing, Parkinson’s disease</topic><topic>Pharmacological agents, levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Respiration Physiology</title></titleInfo><titleInfo type="abbreviated"><title>RESP</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19991201</dateIssued></originInfo><identifier type="ISSN">0034-5687</identifier><identifier type="PII">S0034-5687(00)X0051-5</identifier><part><date>19991201</date><detail type="volume"><number>118</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue pages"><start>77</start><end>264</end></extent><extent unit="pages"><start>163</start><end>172</end></extent></part></relatedItem><identifier type="istex">3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</identifier><identifier type="DOI">10.1016/S0034-5687(99)00075-4</identifier><identifier type="PII">S0034-5687(99)00075-4</identifier><accessCondition type="use and reproduction" contentType="">© 1999Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©1999</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">RESPIRATORY SYSTEM</classCode><classCode scheme="WOS">PHYSIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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